Munlima Hazarika, Satya S Sarangi, Bhargab J Saikia, Partha S Roy, Bibhuti Bhusan Borthakur, Mouchumee Bhattacharyya, Anupam Sarma


Due to limited clinical data in paediatric Ewing’s sarcoma, the aim of this study was to evaluate the demographic characteristics and identifying prognostic factors for survival. We retrospectively reviewed 66 patients with paediatric Ewing’s sarcoma. Median age of presentation was 10 years. Male: Female ratio was 1:1.Femur was the most common site of involvement 13.6% (9/66). The median survival in this study was 52 months. Three and five year survival rate of these patients was 52% and 45% respectively. One out of the 7 patients (14.2%) who did not initiate treatment was alive at the time of analysis whereas 4 out of 8 (50%) patients were alive with incomplete treatment and 35 out of 51 patients (68.6%) were alive who completed treatment and this difference was statistically significant (p<.001).Those patients who completed the treatment protocol had a better survival as compared to those who defaulted or refused treatment.


Paediatric, Ewing sarcoma, Demography, Survival patterns

Full Text:



Ewing J. Diffuse endothelioma of bone. Proc N Y Path Soc 1921;7:17‑24.

Angervall L, Enzinger FM. Extraskeletal neoplasm resembling Ewing’s sarcoma. Cancer 1975;36:240‑51.

Askin FB, Rosai J, Sibley RK, Dehner LP, McAlister WH. Malignant small cell tumor of the thoracopulmonary region in childhood: A distinctive clinicopathologic entity of uncertain histogenesis. Cancer 1979;43:2438‑5.

Rosen G, Wollner N, Tan C, et al. Disease-free survival in children with Ewing’s sarcoma treated with radiation therapy and adjuvant four-drug sequential chemotherapy. Cancer 1974; 33: 384–93.

Glass AG, Fraumeni JF Jr. Epidemiology of bone cancer in children. J Natl Cancer Inst. 1970;44(1):187.

Miller RW. Contrasting epidemiology of childhood osteosarcoma, Ewing's tumor, and rhabdomyosarcoma. Natl Cancer Inst Monogr. 1981;(56):9-15.

Esmati, E. & Safaei, A. & Nosrati, Hassan & Babaei, Mohammad & Hashemi, Farnaz & Farhan, Farshid & Ashtiani, MS & Khanjani, Nezhat & Alibakhshi, Abbas. (2019). Demographic characteristics and prognostic factors in pediatric-type sarcomas; A 7 year single institutional experience and comprehensive review of the current literature. Iranian journal of radiation research (IJRR). 16. 185-195. 10.18869/acadpub.ijrr.16.185.

Ginsberg JP, Woo SY, Hicks MJ, Horowitz ME. Ewing's sarcoma family of tumors: Ewing's sarcoma of bone and soft tissue and the peripheral primitive neuroectodermal tumors. In: Priniciples and Practice of Pediatric Oncology, 4th, Pizzo PA, Poplack DG (Eds), Lippincott, Williams and Wilkins, Philadelphia 2002.

Cotterill SJ, Ahrens S, Paulussen M, et al. Prognostic factors in Ewing's tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing's Sarcoma Study Group. J Clin Oncol. 2000;18(17):3108-3114. doi:10.1200/JCO.2000.18.17.3108.

Smith MA, Gurney JG, Ries LA. Cancer in adolescents 15 to 19 years old. In: Cancer incidence and Survival Among Children and Adolescents: United States SEER Program 1975-1995, Ries, LA, Smith, MAS, Gurney, JG, et al (Eds). SEER program, National Cancer Institute, Bethesda MD, 1999.

Shanmugam S, Govindasamy G, Hussain S, Fells S. Pediatric bone sarcomas: Outcome of multimodality treatment in a single institution in South India over a decade. Indian Journal of Medical and Paediatric Oncology. 2019;40(5):38.

Braveman PA, Cubbin C, Egerter S, Chideya S, Marehi KS, et al. (2005) Socioeconomic status in health research: One size does not fit all. JAMA 294: 2879–2888] [Rabi DM, Edwards AL, Svenson LW, Graham MM, Knudston ML, et al. (2010) Association of median household income with burden of coronary artery disease among individuals with diabetes. Circ Cardiovasc Qual Outcomes 3: 48–53.

Frederiksen BL, Osler M, Harling H (2009) Danish Colorectal Cancer Group, Ladelund S, et al (2009) The impact of socioeconomic factors on 30-day mortality following elctive colorectal cancer surgery: a nationwide study. Eur J Cancer 45: 1248–1256].

Gupta S, Wilejto M, Pole JD, Guttmann A, Sung L. Low socioeconomic status is associated with worse survival in children with cancer: a systematic review. PLoS One. 2014;9(2):e89482. Published 2014 Feb 26. doi:10.1371/journal.pone.0089482.


  • There are currently no refbacks.